RAF Typhoon FGR4s have joined forces with French warplanes in a joint strike on an hidden munitions depot in Syrian territory used by the IS group, as stated by the UK's MoD.
The facility, identified by reconnaissance, was believed to be containing munitions and bombs, the statement said, and was situated in mountains just north of Palmyra in central Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to hit a number of approach shafts down to the facility... initial indications are that the strike was effective," the MoD said.
There was no indication of any harm to civilians in the attack late on Saturday and every plane involved returned to base without incident, the ministry further stated.
The British jets were assisted by a Voyager tanker plane.
The Islamic State group - also known as ISIS - established extremist governance over parts of Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates British leadership, and determination to stand shoulder to shoulder with our allies, to stamp out any resurgence of the terrorist group and their dangerous and violent ideologies in the region," the British Defence Secretary the Defence Secretary stated.
UK warplanes have conducted overwatch operations over Syrian airspace to "deter any attempted comeback" of Islamic State after its routing at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to all the members of our armed forces who took part in this operation for their skill and their bravery," he added. "They were among a great many British troops on duty over the holidays. This mission, to take out terrorist threats who endanger our security, shows how British military are ready to step up, continuously, ensuring Britain's security at home and influential overseas."
In December, the American forces carried out what it described as a "large-scale strike" targeting Daesh sites in Syria, following an ambush resulted in the deaths of two American soldiers and a civilian interpreter in the Palmyra area.
The U.N. says Islamic State still boasts between 5,000 and 7,000 fighters in both countries.
